CCR4 and primary cutaneous T-cell non-Hodgkin lymphoma: Additionally, evidence from several whole-genomic and whole-exon sequencing studies suggests that mutation in NOTCH2 [34], TNFRSF1B, CTLA4-CD28 fusion [132], RB1, PTEN, DNMT3A, CDKN1B [103], CARD11, CDKN2A, and CCR4 [135] can promote CTCL progression.