TP53 and exocrine pancreatic carcinoma: HDAC1 and HDAC2 specifically contribute to the maintenance of mutant p53 function and promote MYC recruitment in various pancreatic carcinoma cell lines, while HDAC8 has been shown to sustain and activate mutant TP53 through the transcription factors HoxA5 and YY1 in breast cancer models [22,23].