Among the significant risk factors identified in the univariate analysis of RFS, clinical factors, including tumor grade (G3), perineural invasion (PNI), circumferential resection margin (CRM) status, the administration of adjuvant chemotherapy and the expression of CD8+ T cells, CXCR3, and Lunit SCOPE IO as TiME biomarkers remained significantly associated with RFS in the multivariate analysis (Table 2). The gene discussed is CD8A; the disease is neoplasm.