CXCR3 binds and traffics toward its IFNγ-inducible ligands, CXCL9, 10, and 11, which are expressed primarily in activated CD8+ T cells, NK cells, and CD4+ TH1 cells and play critical roles in recruiting and retaining T cells during infection, autoimmunity and cancer [26]. The gene discussed is CD8A; the disease is cancer.