In studies, patients with B-cell lymphoblastic leukemia following CAR-T cell therapy presented elevated levels of IL-1α, IL-2, IL-3, IL-5, IL-6, IL-8 IL-10, IL-15, IFN- γ, procalcitonin, CRP, G-CSF, GM-CSF, and MCP-1, and their levels were linked to the severity of neurotoxicity [159,170]. This evidence concerns the gene IL6 and precursor B-cell acute lymphoblastic leukemia.