CD19 and neoplasm: Moreover, the release of various cytokines and chemokines by versatile T cells, such as IFN-γ, MIP-1, IL-8, granzyme B, IL-17A, and IL-5, can alleviate the immunosuppressive effects induced by the tumor microenvironment (TME) and enhance the therapeutic outcomes in CD19 CAR-T cell treatment [69].