Three binding receptors have been identified for iPolyP, namely advanced glycosylation end-product specific receptor (RAGE), purinergic receptor P2Y1, and transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8) [27,28], displaying entirely different transduction pathways, although all three have been linked to CRC progression and development. This evidence concerns the gene TRPM8 and colorectal carcinoma.