With an in vitro approach, we demonstrated that the administration of iPolyP induces the expression of PCNA in Caco-2 (Figure 4A) and in SW620 (Supplementary Figure S2A), non-metastatic and metastatic colorectal cancer cell lines, respectively, without altering the TRPM8 levels (Figure 4A). The gene discussed is PCNA; the disease is metastatic colorectal cancer.