Moreover, similarly to PCNA, we found a strong positive correlation between the concentration of iPolyP within the tumoral tissues and TRPM8 receptor expression (ρ = 0.48, **** p < 0.0001) (Figure 3B), supporting the hypothesis that iPolyP may primarily transduce through the TRPM8 receptor in the CRC context. Here, PCNA is linked to colorectal carcinoma.