Proliferation assays performed on Caco-2 and SW620 with the P2Y1 or RAGE inhibitor demonstrated that iPolyP mainly triggers colorectal cancer cell expansion by binding to TRPM8, as the hindrance of these pathways did not affect the proliferation induced by iPolyP (Supplementary Figure S4C,D). The gene discussed is TRPM8; the disease is colorectal cancer.