EGFR and lung adenocarcinoma: Furthermore, the clinical effects of the combination of HPV 16E6/18E6 expression and EGFR expressions were also analyzed in 173 patients with lung adenocarcinoma, and it was found that patients with lung adenocarcinoma with E6+tEGFR+ had the longest survival time, particularly patients with an older age, no brain metastasis, smoking history, and a wild-type EGFR status [103].