Key pathogenic bacteria such as P. gingivalis and F. nucleatum significantly contribute to cancer development by activating inflammatory pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), extracellular signal-related kinases 1 and 2–E26 transformation-specific sequence 1 (ERK1/2–Ets1), and nucleotide-binding oligomerization domain-containing protein 1/receptor-interacting serine/threonine-protein kinase 2/NLR family pyrin domain containing 3 (NOD1/RIPK2/NLRP3) inflammasome [53,54,55,61]. This evidence concerns the gene RIPK2 and cancer.