GPER1 and cervical cancer: In this study, to elucidate the molecular mechanisms induced by selective GPER activation through G-1, we analyzed the transcriptome of the SiHa cell line derived from cervical squamous cell carcinoma, which accounts for approximately 80% of cervical cancer cases, and of a non-tumorigenic keratinocyte cell line transduced with the E7 oncogene of HPV 16 to simulate an early lesion of this neoplasm.