APOE and glioblastoma: Strategies to modulate BBB permeability are essential for passive endocytosis, as demonstrated by the efficacy of fluoroethyl-modified tyrosine kinase inhibitors [105] and the ARTPC nanoplatform loaded with TMZ and surface-functionalized with ApoE (ApoE-ARTPC@TMZ), which utilizes LDLR-mediated transcytosis for enhanced BBB permeation and anti-GBM activity in vivo [106].