In metaplastic breast cancer tissue samples, immunohistochemical staining revealed that cytoplasmic pEZH2-T367 is significantly higher in cells located at the tumor periphery compared to cells located at the tumor center and that cytoplasmic EZH2 interacts with actin-binding proteins and proteins involved with cell migration (MYO1B, MYO1D, MYO1F, DBNL, and TLN1) [59]. The gene discussed is EZH2; the disease is neoplasm.