HNSCC tumors were stained for the p-EMT markers PDPN, LAMB3, LAMB2, MMP10, TGFB1, ITGA5, and cells that co-stained for p-EMT markers localized to the leading edge of tumors (Figure 3a,b) and near cancer-associated fibroblasts, suggesting that the tumor microenvironment influences p-EMT [81]. The gene discussed is ITGA5; the disease is head and neck squamous cell carcinoma.