Another study found that treatment with Tamoxifen reduces the proliferation of MCF7 breast cancer cells cultured on stiff 100 kPa matrices but does not impact the proliferation of cells cultured on soft 0.1 kPa matrices, and it was determined that the culture of cells on soft matrices promotes chemoresistance by inducing autophagy, which is mediated by ILK [111]. The gene discussed is ILK; the disease is breast carcinoma.