VCL and breast carcinoma: Furthermore, phosphorylation of EZH2 can mediate its subcellular localization and function, and cytoplasmic pEZH2-T367 enhances breast cancer invasion; in breast cancer cells, p38 phosphorylates EZH2 at T367 to induce EZH2 cytoplasmic localization and binding to vinculin, thereby promoting invasion [58].