EZH2 and glioblastoma: Furthermore, drug-tolerant glioblastoma stem cells have increased expression of the histone demethylase KDM6A/B and the corresponding modification H3K27ac and decreased EZH2 and H3K27me3 levels compared to naïve glioblastoma stem cells, and knockdown of KDM6A or KDM6B significantly reduces the emergence of drug-tolerant cells [113].