In relapsing GBM, the presence of tumor macrophages redistributed in the two distinct areas, as the presence of BMDMs increased in the marginal area (p = 0.013) and MG decreased in the central zone (p = 0.002) Found no difference in CD68 cell density between primary and recurrent tumors; recurrent tumors demonstrated increased CD8+ cells (p = 0.015). Here, CD8A is linked to glioblastoma.