TP53 and hereditary elliptocytosis: The combination of the HE pathology with other methods improved the UCAN diagnosis; combining the HE pathology with p53 IHC in the biopsy specimens achieved a sensitivity of 73%, an accuracy of 85% (22/26), and a kappa value of 0.6994, while combining the HE pathology with TP53 mutation analysis resulted in a sensitivity of 87%, an accuracy of 88% (23/26), and a kappa value of 0.7665.