However, high expression levels of these genes in lung adenocarcinoma have been associated with poor overall survival: TKT has been suggested to be a negative prognostic marker in lung adenocarcinoma [45], and UQCC5 (alias SMIM4) has been proposed, together with another six polymorphisms, as a survival prediction tool [46]. This evidence concerns the gene UQCC5 and lung adenocarcinoma.