A recombinant anti-CSPG4 antibody generated with a human IgE Fc backbone triggered greater human macrophage infiltration, induction of pro-inflammatory pathways including TNF, IL-1, IL-12, and IFN, and engendered superior anti-tumour functions in human melanoma xenograft models engrafted with human effector immune cells when compared with the corresponding IgG1. Here, TNF is linked to melanoma.