CD4 and cancer: They engineered a multi-epitope cancer vaccine (P/Tr/Td) via co-aggregation of Coil29 (QARILEADAEILRAYARILEAHAEILRAD) together with the B-cell epitope PEPvIII (LEEKKGNYVVTDH), the CD8+ T-cell antigen Trp2 (SVYDFFVWL), and tetanus toxoid CD4+ T-cell epitope Td (FNNFTVSFWLRVPKVSASHLE).