PRF1 and metastatic neoplasm: While there is currently no specific osteosarcoma antigen(s) reported that can be used to rapidly generate cDCVs for patients with metastatic disease or investigate the genes that are activated in the T-cells following exposure to cDCs, we speculate that there will be induction of the IFN-g, granzyme B, and perforin genes by our cDCV.