CD8A and neoplasm: Using an experimental OS metastasis model, we demonstrated that a cDCV generated using OS tumor cell lysates injected 30 days prior to the intravenous injection of OS cells significantly reduced the formation of lung metastases with increased infiltration of IFNɣ+CD8+ T-cells into tumors, spleen, and tumor-draining lymph nodes (TdLNs) [14].