Likewise, the epigenetic role of the long non-coding RNA (lncRNA) has been linked to vascular invasion in HCC, contributing to its pro-thrombotic effects by activating other target genes such as cyclin-dependent kinase 5 (CDK5), FOS like antigen 2 (FOSL2), and CD44v6 [140,141]. The gene discussed is CDK5; the disease is hepatocellular carcinoma.