It is classified into AML with PML:RARA, RUNX1:RUNX1T1, CBFB:MYH11, DEK:NUP214, RBM15:MRTFA, BCR:ABL1 fusion, or those with KMT2A, MECOM, or NUP98 rearrangement, as well as with mutations in the NPM1 or CEBPA genes. This evidence concerns the gene PML and acute myeloid leukemia.