NPM1 and acute myeloid leukemia: It is classified into AML with PML:RARA, RUNX1:RUNX1T1, CBFB:MYH11, DEK:NUP214, RBM15:MRTFA, BCR:ABL1 fusion, or those with KMT2A, MECOM, or NUP98 rearrangement, as well as with mutations in the NPM1 or CEBPA genes.