The Wnt family of genes has been implicated in the innate immune responses of aquatic animals [45]; Wang et al. [46] reported that the two Wnt homologues (Mn-Wnt4 and Mn-Wnt16) transcripts evidently increased after bacterial and viral infection, and the expression of the wnt6 gene was significantly enhanced in our study. This evidence concerns the gene WNT4 and viral infectious disease.