Our results were consistent with those of Yocomizo [40], where fibronectin plasma and tissue concentrations were elevated in the T1–T2 group and even more so in the T3–T4 cohort, and with those of Hegele [41], where both localized and metastatic ccRCC groups showed significantly higher levels of plasma concentration compared with the controls. This evidence concerns the gene FN1 and nonpapillary renal cell carcinoma.