Also, as the C-terminus of CCL21 is known to interact with, e.g., polysialic acid PTMs present in both the receptor for CCL21 (CCR7) [21] and in the co-receptor NRP2 [22,23] expressed by DCs, other regulatory mechanisms could be affected by basic peptides generated from chemokines through proteolytic activity or released by neutrophils at the site of infection (e.g., hBD2). The gene discussed is CCL21; the disease is infection.