Cañas et al. performed in 2017 the first known proteome (RP-LC-MS/MS) analysis of sEVs released by human eosinophils, detecting proteins implicated in asthma pathogenesis (e.g., ECP, EPO, MBP, periostin) and linked to migration, adhesion, cell signalling, redox, or inflammation [27]. This evidence concerns the gene RNASE3 and asthma.