Pathogenic variants in the TP63 gene are linked to a spectrum of syndromes, including Ectrodactyly, Ectodermal Dysplasia, and Cleft Lip/Palate Syndrome 3 (EEC3); Ankyloblepharon-Ectodermal Defects-Clefting (AEC) Syndrome; Split-Hand/Foot Malformation 4; Orofacial Cleft 8; and others [7]. Here, TP63 is linked to Split hand-split foot malformation.