Among pathogenic B cell subsets, activated naïve [11,12,13,14] as well as double-negative memory B cells, particularly T-bet+CD11c+ age-associated B cells [15,16], CD27− IgD− CXCR5− CD11c+ double negative [17,18,19,20] and CXCR5− CD19low plasmablast precursors [21], are newly identified subsets of autoreactive B cells that are expanded during flares of the disease and are implicated in humoral dysregulation of SLE. Here, CXCR5 is linked to systemic lupus erythematosus.