Additionally, the most common genetic subtype of ALS, linked to intronic hexanucleotide GGGGCC expansions in the chromosome 9 open reading frame 72 gene, exhibits TAR DNA-binding protein 43 mislocalization but also contains additional p62-positive protein aggregates due to pathological dipeptide repeat proteins [99]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.