Interestingly, when PD-1+ and PD-L1+ immune cells were evaluated, taking into account their distribution in tumour tissue, neither these cells’ infiltration in tumour islets nor in tumour stroma demonstrated any significant correlation with prognostic variables; however, it is important to mention that in this case, the evaluated immune cells included not only lymphocytes but granulocytes and macrophages as well [17]. This evidence concerns the gene CD274 and neoplasm.