A significant correlation was found between smoking intensity, evaluated as pack-years, and PD-L1+ lymphocyte infiltration irrespective of their distribution in TME (r = 0.284, p = 0.021 in tumour stroma; r = 0.294, p = 0.016 in tumour islets; r = 0.276, p = 0.025 in total; respectively) as well. This evidence concerns the gene CD274 and neoplasm.