Therefore, we performed whole exome sequencing (WES) on four tumor samples from a patient with MPNST-NF1-associated diagnosis—a benign sample, a primary tumor, a lung metastasis and a skin metastasis—and tested tumor-normal match approaches, with the aim of delineating the molecular alterations that contribute to the progression and metastasis of MPNST. The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.