Through Kaplan–Meier analysis, we observed that a change in expression of RBMX, PNPLA6, C1S, LAMB3, SMC1A and PLOD2 was associated with lower and significant patient survival, as shown in Figure 5A. For the metastatic samples, we chose to perform Kaplan–Meier analysis on common genes filtered for pathogenicity criteria (ACMG/AMP) and integrating lung cancer (LUAD, LUSC) and skin cancer (SKCM) datasets from TCGA. Here, C1S is linked to skin neoplasm.