It has been suggested [471,472] that at least some types of classical amyloidoses have a ‘proteome signature’ that would include serum amyloid P-component (SAP) and heparan sulphate proteoglycans (HSPG), as well as apolipoprotein A4, apolipoprotein E, and vitronectin (see also [62,473,474,475,476]), consistent with some kind of cross-seeding; interestingly, none of these was reported in either the Schofield or Kruger studies, though the latter three proteins were easily observed in normal clots (Figure 17). Here, GPC3 is linked to amyloidosis.