Given that, among the 320 licorice active compounds, the main ones are ER and MR agonists, both ER and MR are present in PTC, and the in vitro anti-cancer properties of licorice in other cancer cultures, the aim of this study was to investigate the possible anti-proliferative role of licorice and GA on PTC cell cultures. The gene discussed is NR3C2; the disease is cancer.