PTTG1 and thyroid gland undifferentiated (anaplastic) carcinoma: They took among the various cell lines studied, one human anaplastic thyroid cancer and one K18 thyroid cancer cell line, and treated them with CDODA-Me and CF3DODA-Me, observing a reduction in both gene and protein expression of pituitary tumor-transforming gene-1 (PTTG-1).