SHBG and obesity due to melanocortin 4 receptor deficiency: For example, it has been observed that adolescents with obesity and lower SHBG were more likely to develop NAFLD/MASLD, with a negative correlation between SHBG and several parameters, including blood pressure, BMI, waist circumference, insulin, and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) [66].