The biological effects of GLP-1 in suppressing lipogenesis, reducing hepatic steatosis and pro-inflammatory responses, and improving cardiovascular outcomes, together with the recognition of FGF21 as a key regulator of metabolism that can improve lipid homeostasis and insulin sensitivity and has an antifibrotic effect, make it an attractive candidate for the treatment of MASLD. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.