GNMT and metabolic dysfunction-associated steatotic liver disease: For example, a study showed that metformin combined with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranoside (PGG), an inducer of glycine N-methyltransferase (GNMT) expression, which is the most downregulated protein in steatosis liver, reversed all biochemical and histopathological features of MASLD [104].