MLXIPL and Insulin resistance: Given the role of glucose and insulin in promoting DNL through activation of carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein-1 (SREBP-1), this process is enhanced in the context of impaired glucose homeostasis and insulin resistance, which are sometimes associated with dietary patterns high in sugar and saturated fat, excess caloric intake, and reduced physical activity [19].