Serum IgE binding to PVs has been widely reported and characterized in many different fish allergies [39], alongside more clinically relevant support such as SPT and basophil activation tests (BAT) [34], while co-sensitization to collagen, GAPDH, aldolase, enolase, creatine, tropomyosin, LDH, TPI, PK, GPI, or alpha-actinin, etc., was partially described in specific fish allergy studies [25,28,40,41]. This evidence concerns the gene IGHE and allergic disease.