Therefore, C2A PAds, which represented a small proportion of the analyzed PAd series, emerged as tumors with a reduced expression of the oncosuppressors CDC73 and CDKN1B, the loss of TP73, and an increased expression of the lncRNAs HAR1B, HOXA-AS2, and HOXA-AS3, sharing features with most common human cancers; this transcript profile was associated with a trend towards more severe PHPT. Here, CDC73 is linked to cancer.