Prognostic factors associated with reduced overall survival (OS) and disease-free survival (DFS) in TNBC include smoking, advanced clinical stage, larger tumor size, angiolymphatic and perineural invasion, positive sentinel lymph node, axillary node involvement, older age, higher cancer burden, and the presence of PIK3CA mutations [40,41,42,43]. The gene discussed is PIK3CA; the disease is cancer.