This highlights the genetic complexity of the DSD phenotype and supports the possibility that the development of DSDs, although not related to a specific Robertsonian translocation, could somehow be associated with rearrangements of chromosome 23 that could potentially affect the regulatory sequences of genes located on chromosome 23 (FOXL2 and CTNNB1) involved in reproductive development [17]. This evidence concerns the gene CTNNB1 and disorder of sexual differentiation.