HMGB1 and cancer: So far, six DAMPs have been mechanistically linked to the perception of RCD as immunogenic: (1) calreticulin (CALR), (2) ATP, (3) high-mobility group box 1 (HMGB1), (4) type I interferon (IFN), (5) cancer cell-derived nucleic acids, and (6) annexin A1 (ANXA1) [72].