Indeed, intramuscular injection of Pgk1 was shown to significantly reduce or delay neuromuscular junction (NMJ) denervation in Rtn4al-overexpressing Amyotrophic lateral sclerosis (ALS)-like zebrafish and SOD1-mutated ALS-like mice, leading to improved muscle contraction and mobility [29,30]. Here, PGK1 is linked to amyotrophic lateral sclerosis.