Both AD and CVD were associated with longitudinal changes in fourteen proteomic biomarkers (α1Micro, ApoH, β2M, BNP, complement C3, cystatin C, KIM1, NGAL, PPP, TIM1, THP, TFF3, TM, and VEGF) (Table 2), of which four were also associated with MCI. This evidence concerns the gene B2M and Alzheimer disease.