A recent study reported that they were able to predict, with accuracy, the risk of a person with MCI progressing to dementia due to AD in a time period of up to four years by using a machine learning-based panel composed of 12 plasma proteins (ApoB, Calcitonin, C-peptide, CRP, IGFBP-2, Interleukin-3, Interleukin-8, PARC, Serotransferrin, THP, TLSP 1-309, and TN-C) that included THP [57]. The gene discussed is CALCA; the disease is Alzheimer disease.