Both AD and CVD were associated with longitudinal changes in fourteen proteomic biomarkers (α1Micro, ApoH, β2M, BNP, complement C3, cystatin C, KIM1, NGAL, PPP, TIM1, THP, TFF3, TM, and VEGF) (Table 2), of which four were also associated with MCI. Here, C3 is linked to Alzheimer disease.