NFKB1 and cancer: In HCC, the NF-κB pathway may also be overactive, but in this type of cancer, NF-κB has been observed to respond to oxidative stress by regulating the gene expression of reactive oxygen species scavenging proteins.In the case of HCC, chalcones that inhibit NF-κB can reduce oxidative stress and improve the immune response, which leads to different therapeutic effects compared to colorectal cancer [1].