NLRP3 and gout: Furthermore, the results are also in line with previous data showing that complex leaf extracts rich in Di-CQA obtained from Artemisia selengensis Turcz could alleviate gout inflammation in an in vitro model of THP-1 cells by inhibiting the NLRP3 inflammasome and activating the NRF2 signaling pathway and thus the production of several pro-inflammatory cytokines [24].