Here, we have confirmed the capacity of Cy3,5DiG to reduce not only the production of IL-6 by human macrophages in vitro as a single agent but also the production of TNF-α, one of the other major pro-inflammatory cytokines mediating inflammatory-related pathologies such as Crohn’s disease (CD) [36] and rheumatoid arthritis (RA) [37]. The gene discussed is TNF; the disease is rheumatoid arthritis.