Second, four out of nine signature proteins downregulated in patients with AD and food allergies (i.e., Krt77, Asah1, Ggh, Cat) were significantly decreased in the RoraEKO epidermis vs. the control (Figure 3C,D), indicating RORα could be critical for maintaining the expression levels of these important genes [43]. This evidence concerns the gene ASAH1 and food allergy.