Interestingly, when we analyzed the probability of mutations in the genes associated with malignant transformation, such as tumor suppressors or oncogenes, we observed that KDM3B expression was associated with a reduced mutation risk in the tumor suppressor genes, such as TP53 and BRCA2, and proto-oncogenes, such as BRAF (Figure 4B). This evidence concerns the gene TP53 and neoplasm.