DES and familial dilated cardiomyopathy: DCM also is a common disease of the heart muscle; it is often classified as idiopathic and without an identifiable cause, although a familiar and genetic predisposition is demonstrated, and DCM has been associated with variants in genes encoding for Titin (e.g., TTN) [26], Desmin (e.g., DES) [27], Lamin (e.g., LMNA) [28], and Myosin (e.g., MYH7 and MYH6) [29,30].