In the present study, we extend these findings to investigate the impact of NSCLC-associated miRNAs on oncogenic signaling in naïve lung bronchial epithelial cells, with a focus on genes within the LINE-1 regulatory network identified as putative targets including, ICAM-1, AGL, VCAM1, VAMP3, RBM39, PKIA, and RGS. Here, PITX2 is linked to non-small cell lung carcinoma.