GLB1 and Fabry disease: Thus, Niemann–Pick disease (NP), Gaucher’s disease (GD), Farber disease (FARD), Fabry disease (FD), and Krabbe’s disease (KD) are caused by the deficiency of sphingomyelinase, beta-glucocerebrosidase, ceramidase, alpha-galactosidase, and beta-galactosidase, respectively, with the accumulation of sphingomyelin, glucosylceramide, ceramide, trihexosylceramide, and galactosylceramide (Table 1).