While 28 RA sera tested positive for the four chimeric enolase peptides, a greater number of sera (33) were positive for the chimeric peptides that are composed of the filaggrin or fibrin sequences covalently linked to the CEP-1 peptide (CFECHAP-1, CFECHAP-2 and CEFCHAP). This evidence concerns the gene FLG and rheumatoid arthritis.