AKT1 and cancer: Particularly, KEGG pathway analysis indicated that signaling pathways related to calcium and cancer stemness, including Notch, Wnt, PPAR, PI3K/Akt, and TGF/SMAD, were significantly more activated in lenvatinib-resistant PTC than in lenvatinib-sensitive PTC (Figure 1C, top and bottom) [23,24,28,29,30].