AE is associated with autoantibodies against synaptic receptors, neuronal cell surface proteins, and neuronal intracytoplasmic antigens, including NMDAR encephalitis leucine-rich glioma-inactivated 1 (LGI-1), γ-aminobutyric acid type B receptor (GABAbR), and contactin-associated protein-2 (CASPR2) antibodies [197,198,199]. The gene discussed is CNTNAP2; the disease is acrodermatitis enteropathica.