RNASE3 and multiple sclerosis: In addition, an increase in eotaxin-2, eotaxin-3, and eosinophil cationic protein (ECP), which contribute to the recruitment and activation of eosinophils, was observed in the CSF of patients with NMOSD compared to patients with multiple sclerosis and healthy controls, and apparent infiltration of eosinophils around the perivascular and meningeal space was observed in the active NMOSD lesion, suggesting the contribution of eosinophils to the pathogenesis of NMOSD [110,123].