This is in opposition to the observed beneficial effects of vitamin D supplementation in the pediatric population with overweight and obesity, where authors concluded that vitamin D exerts an anti-inflammatory effect via decreasing the CRP levels and protecting stable values of IL-10 with less effect on pro-inflammatory factors such as lL-17 and leukocyte profile parameters [30]. This evidence concerns the gene IL10 and obesity due to melanocortin 4 receptor deficiency.