TNF and neuroblastoma: On the other hand, analysis of the SNP -308 G/A rs1800629 TNF-α SNP with clinicopathologic factors of patients with NB, we only observed that the majority of patients with A allele presented high-risk NB (p = 0.04) and unfavorable tumor histology (p = 0.03) (Table 4); it has been reported that the presence of the -308A allele correlates with increased TNF-α production in vitro and in vivo [21,22].