EDNRB and cancer: On the other hand, in the S-phase samples, genes related to negative regulation of apoptotic processes (XIAP, EDNRB, and SOD2) and pathways in cancer (LAMB3, IL6ST, and HIF1A) were significantly upregulated in the sEMS group compared with the sCT group, while genes related to responses to hypoxia (PAM) and the Rap1 signaling pathway (MAP2K6) were significantly downregulated in the sEMS group compared with the sCT group (Figure 7b).